The Cleveland Children’s Sleep and Health Study is one of the
largest cohorts developed to study risk factors and outcomes of sleep apnea in
children. 850 children, ages 8-11 years, from a birth cohort including full
and preterm (50%) children have been studied with sleep studies, neurocognitive
and behavioral assessments, anthropometry, blood pressure, and spirometry. Of
these children, 250 are targeted for reassessment at ages 13 to 16 years, with
repeated measurements of these factors as well as actigraphy (measuring average
sleep time), and metabolic outcomes (e.g., insulin resistance) and hormonal
perturbations. The study provided the most precise quantification of the prevalence
of sleep apnea in middle childhood, and uniquely identified prematurely as a sleep
apnea risk factor, as well as African American race.
References
- Rosen CL, Storfer-Isser A, Taylor HG, Kirchner HL, Emancipator JL,
Redline S. Increased behavioral morbidity in school-aged children with
sleep-disordered breathing. Pediatrics 2004 Dec;114(6):1640-1648.
- Larkin EK, Rosen CL, Kirchner HL, Storfer-Isser A, Emancipator JL,
Johnson NL, Zambito AM, Tracy RP, Jenny NJ, Redline S. Variation of C-Reactive
Protein Levels In Adolescents: Association with Sleep Disordered Breathing
and Sleep Duration. Circulation 2005. (in press).
- Spilsbury J, Storfer-Isser A, Drotar D, Rosen CL, Kirchner HL, Benham H,
Redline S. Sleep behavior in an urban U.S. sample of school-aged children.
Archives Pediatr Adolesc Med 2004 Oct;158(10):988-994.
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