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Cleveland Family Study |
The Cleveland Family Study is a longitudinal
genetic epidemiology study designed to investigate the genetic and non-genetic
etiology of sleep apnea. It represents the largest family-based study of the
genetics of sleep apnea. Since 1990, over 2600 members (ages 4 to 96 years; 40%
African American) from > 350 families have been studied on as many as four
occasions. Two thirds of families were selected because of a single proband
with sleep apnea; one third were selected as neighborhood controls. Extensive
phenotype data have been collected initially with in-home exams, and later with
exams in the UH General Clinical Research Study, including overnight sleep
studies, anthropometry, blood pressure, spirometry, and with recent addition of
blood and urine assays for hormones and cytokines, endothelial reactivity, and
expired nitric oxide. DNA has been collected, with a genome scan, performed at
the NHLBI Center for Mammalian Genetics, in >1300 individuals. The study was
the most rigorous study to quantify the heritability of sleep apnea, and the
first to report linkage analyses for the apnea hypopnea index.
References
- Palmer LJ, Buxbaum SG, Larkin E, Patel SR,
Elston RC, Tishler PV, Redline S. A whole genome scan for obstructive sleep apnea and obesity in African-American
families. Am J Respir Crit Care Med 2004:169(12):1314-1321.
- Palmer LJ, Buxbaum SG, Larkin E, Patel SR,
Elston RC, Tishler PV, Redline S. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum
Genetic. 2003;72(2):340-50.
- Tishler PV, Larkin EK, Schluchter MD, Redline S. Incidence of sleep disordered
breathing in an urban adult population: the relative importance of risk factors
in the development of sleep-disordered breathing. JAMA. 2003;289(17):2230-2237.
- Buxbaum SG, Elston RC, Tishler PV, Redline S.
Genetics of the apnea hypopnea index in Caucasians and African Americans:
I. Segregation Analysis. Genet Epidemiol. 2002; 22(3): 243-53.
Contacts
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